Scientific Program Analyst Job at GAP Solutions, Inc., Bethesda, MD

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  • GAP Solutions, Inc.
  • Bethesda, MD

Job Description

Position Objective: Provide services as a Scientific Program Analyst in support of the overall functions of the Laboratory of Malaria Immunology and Vaccinology (LMIV), Division of Intramural Research (DIR) within the National Institute of Allergy and Infectious Diseases (NIAID).

Duties and Responsibilities:

  • Assist with vaccine development initiatives, including the production of vaccines for Phase 1 and 2 vaccine trials.
  • Independently develop scalable fermentation processes, and support purification processes for production of recombinant malaria antigens produced by Saccharomyces cerevisiae, Escherichia coli or Pichia pastoris and Myceliophthora thermophila
  • Provide support to the Federal Task Leader (FTL) including but not limited to: small-scale and pilot-scale (60L) fermentation development.
  • Provide analysis of approaches for harvesting, purification development of scalable procedures.
  • Provide support to the analytical effort providing laboratory reagents for HPLC analysis.
  • Provide technical transfer of fermentation processes to a CDMO to support cGMP manufacturing and serving as the main Point-of-Contact.
  • Provide support in the development of design-of-experiment models for fermentation optimization and using Eppendorf fermenters and software, Raven methanol sensors, Akta Explorers, YSI Bioanalytical instruments and equivalent equipment to analyze products.
  • Perform various scientific experiments using Western blotting procedures, endotoxin testing and other HPLC/UPLC methods.
  • Record and analyze data using JMP software, Microsoft Word, PowerPoint, Excel and graphics programs.
  • Works with FTL to organize scientific data into a format that is suitable for manuscript publications to share discoveries with the scientific community.
  • Prepare various media, buffers, stock supplies, and other reagents for use in the laboratory, and maintain lab upkeep.

Basic Qualifications:

  • Minimum of a Bachelor degree in a science related field with at least four (4) years of experience using Eppendorf Scientific fermentations sytems at a variety of scales is required.
  • Minimum of four (4) years of related experience working in a scientific laboratory studying protein expression and purification is required.
  • Experience at scale up, scale down fermentation processes using a variety of microorganisms especially Pichia pastoris and Myceliophthora thermophila C1.
  • Experience at the generation of ferritin nanoparticles using the novel expression system Myceliophthora thermophila C1 to produce novel drug products that can be used in preclinical and clinical evaluation studies.
  • Experience with Design of Experiments to optimize process parameters to identify optimal processing parameters to optimize cellular production of proteins used to create vaccines.

Minimum Qualifications:

  • Understanding of malaria and malaria vaccinology is highly desired.
  • Previous working experience at NIH is highly desired.
  • Ability to communicate effectively, orally and in writing, to share information with the FTL and other lab staff.
  • Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
  • Familiar with using SharePoint, TEAMS, and Microsoft Office Suite programs.
  • Able to work alone and professionally as part of a team to accomplish assigned tasks in a timely manner.

*This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job, email us at recruiting@gapsi.com . You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.

Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.

This position is contingent upon contract award.

Job Tags

Contract work, Work experience placement, Work alone,

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